We have known for decades that blood transfusion is a
life-saving medical intervention. Just
ask any survivor of severe traumatic injury, a complicated surgical procedure,
or cancer, where necessary chemotherapy slowed the body’s ability to replace
oxygen carrying red blood cells, infection fighting white blood cells or hemorrhage
stopping platelets: Transfusion saves
lives. However, an accumulating body of data
also shows that there are significant risks associated with transfusion, and in
some circumstances, those risks may outweigh the benefits. For example, a large meta-analysis of
transfusion data published in early 2014 in the Journal of the American Medical
Association found that a restrictive approach to transfusion, i.e., giving less
blood rather than more, was safer for many patients. These researchers found that the risk of
serious hospital-acquired infection was lowered substantially among patients
whose doctors ordered a blood transfusion at a lower hemoglobin level, compared
with those whose caregivers used a higher cutoff [1]. For surgical patients, blood transfusion has been
associated with more postoperative pulmonary and infectious complications,
prolonged ventilator support, and higher mortality.
In response to these and other data, today there is broad
recognition that we should improve overall
patient blood management. Broadly defined, patient blood management is
an evidence-based, multidisciplinary process that is designed to promote
optimal use of blood products in the hospital.
This concept places patient safety first, and includes transfusing only
when medically necessary, thus potentially reducing overall patient morbidity
and mortality. In the cost conscious
medical environment of today, a secondary goal of blood management is reduction
of costs associated with treating any adverse events we now understand could be
associated with transfusion, as well as just not having to collect, process and
transfuse as much blood.
Throughout the state, many of the hospitals we serve have embraced patient blood management. At one hospital, posters reminding physicians to
carefully consider transfusion requests are prominently displayed in physician
elevators and other areas. At another, blood utilization and management data spanning several
years was published as an abstract at the AABB 2013 national meeting,
entitled “Reducing Platelet and Red
Blood Cell Utilization in a 325 Bed Hospital” [2; on display, 4th
floor, Main Lab TMF]. Dr. Bobbie
Sutton, Medical Director of Blood Donor Services and Blood Bank Services at The
Medical Foundation, has lectured about Blood Management to multiple groups regionally. Dr
Sutton is working with clinicians at facilities to update existing
transfusion policies and better reflect these new ideas. “The data is out there, and the time to act
is now” she says. “Having shared
hospital transfusion criteria in our region as a readily available practice
guide for all physicians is a big step in the right direction. It should facilitate more appropriate blood
utilization and transfusion data review.”
1. Rohde JM, Kimcheff
DE, Blumberg N et al. Health
Care-Associated Infection After Red Blood Cell Transfusion. A Systematic Review and Meta-analysis. JAMA 2014;311(13): 1317.
2. SuttonBC,
RobertsD, Wright M et al. Reducing
Platelet and Red Blood Cell Utilization in a 325 Bed Hospital. 2013 AABB National Meeting. Poster AP1.